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Applying a topical numbing cream like lidocaine to the injection site 10 minutes before your shot provides mild anesthesia, though many patients find it unnecessary once they've completed two or three injections without complication

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Additionally, no significant differences in cardiovascular protection were found between the two therapies in patients with poorly controlled diabetes (HbA1c 8.0)

More studies are required to understand whether and how exogenous cannabis administration, as well as different components of the endocannabinoid system, may have direct and/or indirect influences on the GLP-1 system